A Short History of Viral Hepatitis

Far away in BC 460 ~ 375 years, Western medicine Hippocrates, the father of the "medical disease" mentioned that "epidemic jaundice." China's "Yellow Emperor" also has jaundice account. Han Zhang Zhongjing book "Treatise on Febrile Diseases" and "Golden Chamber" will be divided into 5 types of jaundice, Tang Dynasty, Sun Ssu-in "Qian Jin Fang", he also added to the "wet yellow." Song jaundice will be divided into "Yin Wong," and "Yang Huang," two categories. Described in ancient times mostly jaundice icteric viral hepatitis.

1858 Bambecga that the opening in the common bile duct obstruction is a cause of inflammation, known as "obstructive jaundice." 1868 Virchow discovered that the common bile duct embolization caused by mucus, called "catarrhal jaundice." The beginning of 1940 proved to be the liver inflammation. Followed by Dr. Su Lian at first said that liver damage is mainly systemic infections, called "special package's disease." 1939-1945 years during World War II took place not strictly a result of syringe disinfection of serum hepatitis epidemic due to suspected viral. 1973 Feinstone, etc. from a patient with immuno-electron microscopy of hepatitis A virus found in feces, through fecal transmission, then known as infectious hepatitis (hepatitis A), by serum-borne is called serum hepatitis (hepatitis B).

Australia antigen was found in 1965, Brumberg. 1968, recognizing the antigen and hepatitis related to hepatitis-associated antigen that (HAA), that is, the performance of today's hepatitis B antigen (HB-sAg). The discovery of hepatitis HBsAg identification, serological diagnosis and prevention of auto-passive immunization of great value. Brumberg has also earned the 1976 Nobel Prize in Medicine.

Dane with the immune electron microscopy in 1970 to complete hepatitis B virus (HBV) particles. Of hepatitis B vaccine to prevent hepatitis B by KrugMam first proposed, has been widely used.

1979, hepatitis A antibodies can be detected.

70s of last century found a non-A, non-B hepatitis. Until September 1989, it will be transmitted by transfusion of non-A non-B hepatitis called hepatitis C infection through the digestive tract of non-A non-B hepatitis called hepatitis.

Rizzetto, etc. in Italy in 1977 found that patients with HBsAg-positive liver cell nucleus there is a new antigen, said the Q factor, was named in 1983, hepatitis D virus (HDV). Was recognized that it alone, the total overlap with the hepatitis B infection, jackal to the tiger, siding with the bully.

Today, these five types of viral hepatitis can be detected in a number of hospitals identified. Subsequently found in sporadic acute hepatitis and chronic post-transfusion hepatitis in many cases, using existing diagnostic techniques can be sensitive to exclude A, B, C, D, hepatitis E, therefore, there may have been-and G-type hepatitis . 1996 Linnen and other officially reported hepatitis G virus (HGV).

In addition to the above, there are a number of viral infection can cause inflammation of the liver disease, mostly systemic symptoms, but mainly, the liver inflammation, mostly secondary, not typical. Such as intestinal virus, rubella virus, measles virus, adenovirus, HSV, VZV, EB virus can cause viral hepatitis.